Endocrine Abstracts

Objective: Polycystic ovary syndrome (PCOS) is characterized by biochemical and clinical androgen excess and disturbed ovarian function and is associated with disorders of glucose and lipid metabolism. Isoflavones are phytoestrogens exerting endocrine effects on human hormone and metabolic signaling and may influence symptom penetrance in PCOS. We investigated whether women with PCOS and healthy controls have alterations in their capacity to metabolize hormonally active dietar...

Background: The aim of this study was to evaluate salivary androgen measurements via liquid chromatography-mass spectrometry as a non-invasive tool for the diagnosis of polycystic ovary syndrome (PCOS) and the assessment of metabolic health.Methods: Saliva and serum samples of 274 patients with PCOS fulfilling Rotterdam criteria and 51 BMI-matched, premenopausal, healthy controls were analysed for steroid hormones using liquid chromatography/mass spectro...

Objective: Polycystic ovary syndrome (PCOS) affects 5–20% of women of reproductive age worldwide and is associated with disorders of glucose metabolism. Hormone and metabolic signalling may be influenced by phytoestrogens, such as isoflavones. Their endocrine effects may modify symptom penetrance in PCOS.We investigated, whether women with PCOS and healthy controls differ in their capacity to metabolize dietary isoflavones and whether this capacity...

Aim: Gastric bypass surgery improves glycaemic control, but the underlying mechanisms including potential changes in adipoinsular axis are incompletely understood. The aim of this study was to investigate potentially causal or associated alterations in gene expression of adipokines, myokines, and hormones in the subcutaneous and visceral adipose tissue of diabetic and non-diabetic obese subjects before and after gastric bypass.Material and methods: Biops...